The present study investigates the physicochemical and biological characteristics of 45S5 bioglass under conditions of its interaction with a buffer solution simulating a biological environment. The primary focus was placed on examining biodegradation and the dynamics of acid-base balance changes in the model medium. It has been confirmed that the effectiveness of the material for biomedical applications is determined by the particle size employed. The study addresses the problem of accurate fractionation and provides a comparative analysis of two sample preparation methods: wet and dry sieving. It was established that wet sieving promotes the removal of fine fragments from the surface of larger fractions and reduces the material's influence on local alkalinization of the medium. Using Ehrlich ascites adenocarcinoma cells, it was demonstrated that the cytotoxic effect is attributable to chemical necrosis induced by the alkaline environment localized at the surface of the bioglass particles. It is concluded that the material holds potential for application in the field of adjuvant therapy for malignant neoplasms. The findings obtained are of significant importance for the development of novel biomedical implants and therapeutic systems.
Dina N. Grishchenko – Candidate of Chemical Sciences, senior researcher, Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
Michael A. Medkov – Doctor of Chemical Sciences, Professor, head of the Laboratory, Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
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