The results of the development of powdered nanoporous glass (NPS) with a controlled pore size for solid-phase synthesis of oligonucleotides with an increased product yield are presented. By varying the parameters of thermal and chemical treatment of sodium-borosilicate glasses, an NPG with a narrow pore size distribution was obtained. It was found that the functional loading of the material was 72 ?mol / g. It was shown that the use of the developed NPS in the synthesis of long-chain oligonucleotides more than 7 times increases the product yield in comparison with similar material on the market.
Cand. chem. Sci. G. Yu. SHAKHGILDYAN
1 (
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ), K. I. PYANZINA
1 , A. A. STEPKO
1 , A. N. NATYROV
2 , A. M. MIKHAILOV
1 , Cand. tech. Sci. V. I. SAVINKOV
1 , Dr. Sciences V. N. SIGAEV
1 ;
1 Federal State Budgetary Educational Institution of Higher Education & # 171; Russian Chemical-Technological University named after V.I. D. I. Mendeleev & # 187; (Russia, Moscow)
2 LLC & # 171; NPF Syntol & # 187; (Russia, Moscow)
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