On the basis of oxides of zirconium, titanium and aluminum, a method has been developed for producing porous ceramics biocompatible with living tissues by introducing calcium phosphates into the volume of ceramics. The bioactive coating is formed directly during the manufacturing process of the sample. The resulting two-phase ceramic is characterized by a developed microrelief. Specimens meet the mechanical specifications for bone replacement implants
Calcium phosphate powder was synthesized from calcium formate Ca (CHO 2 ) 2 and ammonium hydrogen phosphate (NH 4 ) 2 HPO 4 at the Ca / P ratio in the initial aqueous solutions equal to 1. The phase composition of the powders synthesized from solutions with a concentration of 0.5 M was represented by brushite CaHPO 4 .2H 2 O and octacalcium phosphate Ca 8 (NPO 4 ) 2 (PO 4 ) < sub> 6 · 6Н 2 O. The phase composition of the powder after firing at 1100 & # 176; C was represented by calcium pyrophosphate & # 946; -Ca 2 P 2 O 7 and tricalcium phosphate & # 946; -Ca 3 (PO 4 ) 2 . The synthesized powder can be used to obtain biocompatible resorbable biphasic ceramic materials and composites with a polymer matrix.
Composite bioceramics with a density of at least 80% of the theoretical was obtained from thermolyzed octacalcium phosphate (OCP). OCP processing temperatures were 450, 600, and 700 ° C. Ceramics were obtained by firing thermolyzed powders at a maximum temperature of 1000, 1050, and 1100 ° C with holding for 3, 6 and 9 h. The highest strength characteristics (up to 125 MPa when measuring the flexural strength) are demonstrated by samples obtained from OCP treated at 450
The influence of the surface properties of the developed calcium silicophosphate glass-crystalline materials and coatings on their biocompatibility has been determined. The ratio of calcium to phosphorus on the surface of materials and coatings for the formation of an apatite-like layer on them, as well as the optimal values ??of the roughness parameter and free energy of the surface for the adsorption of protein molecules and adhesion of bone-forming cells have been established.
The analysis of the processes of phase formation in open systems CaX 2 -M 2 NRO 4 / M 3 PO 4 -Na 2 SiO 3 -Н 2 O. According to the calculated values ??of & # 916; G crystallization, the possibility of forming mixtures of hydroxyapatite and calcium silicate in alkaline solutions was established. It has been shown that the precipitation of calcium carbonate is also probable in the case of "wet" synthesis in an air atmosphere. Ca 10 (PO 4 ) 6 (OH) 2 , CaSiO 3 and CaCO 3 possess the property of bioactivity, which makes it possible to use the studied system for obtaining polyphasic materials for bone tissue engineering
A 3D matrix was obtained based on a sintered composite material made of bioactive glass and dicalcium phosphate dihydrate. The regularities of the influence of the ratio of the mixture components and the firing temperature of the workpieces on the phase composition, porosity, strength and kinetics of dissolution of sintered specimens have been established. The possibility of directed formation of highly resorbable phases in sintered composites is shown. A personalized implant was obtained using the 3D modeling method
Sol-gel method synthesized thin films based on the SiO 2 -CаO-P 2 O 5 -TiO 2 system ... The properties of the material were investigated by methods of infrared spectroscopy, X-ray phase analysis, and thermal analysis. Thin films were obtained from film-forming solutions (FOR) on single-crystal silicon substrates (model substrate) by stretching at a pulling rate of 5 mm / s followed by heat treatment at 60 ° C for 20 min and at 600 and 800 ° C for 1 h. Biological activity was studied in vitro in SBF environment. With an increase in the mass content of titanium oxide in the system up to 10%, the bioactivity of the material increases.
Ceramics based on calcium phosphates are obtained from powders synthesized from aqueous solutions of calcium nitrate, ammonium hydrogen phosphate, ammonium pyrophosphate and from a mixed-anionic solution containing both pyro- and ammonium orthophosphate at a molar ratio (NH 4 ) < sub> 2 HPO 4 / (NH 4 ) 4 P 2O7 equal to 1. Received ceramics contains biocompatible bioresorbable phases and can be used for the manufacture of implants used in regenerative methods for treating bone tissue defects. The use of synthesis from mixed-anionic solutions to obtain powders of calcium phosphates with a significant content of each of the anions is presented for the first time
The description of the information system containing reference information on the physicochemical, biological properties of orthophosphates, pyrophosphates and ultraphosphates of calcium is given. In addition to reference information, the system contains an array of publications from various domestic and foreign search engines on the presented classes of calcium phosphates, as well as implantation materials based on them. The descriptions of the user and search interfaces of the system intended for specialists in the field of inorganic materials and medical materials science are given.
Calcium-silicophosphate glass-crystalline coatings on titanium alloys were obtained by slip technology and their properties were investigated. The type and the optimal amount of the suspending additive have been selected to ensure the required properties of the slip. The operating parameters for applying these coatings to titanium alloys have been established.
