Calcium hydroxyapatite (HAP) powder is synthesized from an aqueous solution of potassium hydrogen phosphate and a suspension of calcium hydroxide in an aqueous solution containing calcium and potassium ions, hydroxide ions and acetate ions. The amount of Ca (OH) 2 in the calcium-containing component was 50, 75 and 100%. The synthesized HAP powder was used to obtain ceramics. Ceramics after firing at 700 ° C from HAP powder containing a by-product of the reaction had a density of 2.0 - 2.6 g / cm 3 and a flexural strength of 35 - 45 MPa at a grain size of 200 nm. The phase composition was represented by HAP and double calcium orthophosphate of potassium. Ceramics based on HAP, after firing at 1200 ° C from a powder that does not contain a by-product of the reaction, had a density of 2.2 - 2.3 g / cm 3 and a flexural strength of 45 - 55 MPa at a grain size 500 - 1000 nm. Tab. 2, ill. 11, bibliography: 14 titles.
The issues of the possibility of using composite ceramics based on biogenic hydroxyapatite (BHA) as carriers of cultured stem cells are considered. The results of studies of the microstructure and biochemical activity of glass-ceramic samples based on BHA with a maximum fraction of open porosity, prepared for use as substrates for cloning fibroblast cells in vitro, are presented. The results of a visual assessment using fluorescence microscopy of cell adhesion and their proliferative activity on bioresorbable membrane-type substrates made of a composite material based on biogenic hydroxyapatite are also presented. Tab. 2, ill. 4, bibliography: 8 titles.
By the method of high-temperature X-ray diffraction, the presence of a reversible polymorphic transformation of both synthesized stoichiometric leucite and precipitated as a result of crystallization of glasses was established. The established temperature limit of this transition for leucite, which is in the composition of glass-crystalline material, shifts to a region of lower temperatures in comparison with the modification transition of synthetic leucite. Il. 2, bibliography: 9 titles.
The properties of the powder synthesized from calcium acetate and sodium hydrogen phosphate were studied at the ratio [Ca 2+ ] / [PO 4 3- ] of the initial reagents equal to 1. Brushite, monetite, octacalcium phosphate were found in the powder after synthesis. A significant weight loss of 26% upon heating is due not only to the decomposition of the detected phases, but also to the removal of the by-product present in the powder of the reactions occurring during the interaction of solutions of the starting materials consisting of sodium acetate and acetic acid. After firing at temperatures above 900 ° C, the phases ?-Ca 2 P 2 O 7 , ?-Ca were found in the samples 3 (PO 4 ) 2 and Ca 10 Na (PO 4 ) 7 .
Tab. 1., ill. 6, bibliography: 13 titles.
The properties of Ca-deficient hydroxyapatite powder synthesized from calcium nitrate and ammonium hydrogen phosphate at 60 ° C, pH = 7 and Ca / P = 1.67 are presented; 1.61 and 1.48. After firing at 1100 ° C for 6 h, the phase composition of the ceramics based on these powders was represented by tricalcium phosphate (with Ca / P = 1.48) or tricalcium phosphate and hydroxyapatite (with Ca / P = 1.67 and 1.61). The grain size of the ceramics was 100 - 1000 nm. Tab. 2, ill. 3, bibliography: 18 titles.
Domestic and foreign implantation materials for elimination of defects and deformations of bone tissues are considered. Comparative results of experimental morphological studies of these drugs are presented. The main results of the joint scientific and practical activities of the staff of the laboratory of the FSUE "TsNIIAG" and the specialists of the maxillofacial clinic of the State Institution MONIKI are presented. A new silicocalcium phosphate bioceramic is described for replacing bone defects in maxillofacial surgery, dentistry, neurosurgery and traumatology. Tab. 1, ill. 6, bibliography: 12 titles.
The results of a two-stage synthesis of tricalcium phosphate by the wet method followed by high-temperature treatment are presented. The influence of the introduction of tricalcium silicate and alkaline silicate glasses in the formation of biocomposite materials based on dicalcium phosphate dihydrate (DCPD) is considered. It was found that the use of bioactive glass 50S25N5P in an amount of up to 10% by weight increases the compressive strength and pH values ??to a physiologically safe level in the composite material in comparison with unmodified DCPD. The resulting composite ensures the formation of osteoid tissue for 30 days. Il. 6, bibliography: 4 titles.
The possibility of synthesizing ceramic composites based on mixtures of powders of two types of biocompatible glasses and potassium polytitanate has been investigated. It is shown that in the course of interaction of the obtained composites with a solution simulating blood plasma, a porous structure is formed on the surface of the material, reinforced with fibers of potassium hexatitanate or calcium titanate; at the same time, the pores are filled with hydroxyapatite, which should facilitate the growth of bone tissue into the structure of implants made on their basis. Tab. 2, ill. 2, bibliography: 12 titles.
The formation of the microstructure of ceramics based on calcium hydroxyapatite (HAP) powders containing various by-products of the synthesis reaction - NaCl, KCl, KCH 3 COO (K 2 СО 3 < / sub>), NaCH 3 COO (Na 2 СО 3 ), NH 4 NO 3 , NH 4 Cl, NH 4 CH 3 COO, which can be conditionally divided into two groups: removed during heat treatment before sintering and not removable, forming melts and promoting the formation of new phases. During heat treatment, sodium salts interact with HAP, forming double sodium calcium phosphates - renanite NaCaPO 4 and Ca 10 Na (PO 4 ) 7 , and acetates of alkali metals (Na, K) are double carbonates. Il. 7, bibliography: 4 titles.
Bioinert ceramics based on partially stabilized tetragonal zirconium dioxide have been developed, and their chemical and phase compositions, microstructure, and physical and technical characteristics have been investigated. Ceramic heads of hip joint endoprostheses with a diameter of 28 mm with a spherical surface roughness R a less than 0.02 µm and a deviation from sphericity of 1 µm were made. It is shown that the developed bioceramics and ceramic heads of endoprostheses made of it meet the requirements of international standards in terms of technical characteristics and parameters and are not inferior to similar products from well-known companies. Tab. 2, ill. 3, bibliography: 8 titles.
